Isoetharinewith Phenylephrine Aerosol in Asthma

نویسنده

  • GEORGE G. SPELLMAN
چکیده

The bronchodilator effect of fenoterol hydrobromide (0.5, 1.25, and 2.5 mg) was compared with either isoproternol (2.8 mg) or isoetharine (5 mg) with phenylephrine (1.25 mg) in a double-blind placebo-controlled study. When delivered by an intermittent positive-pressure breathing device to 24 nonsmoking young adult asthmatic subjects, fenoterol produced significant improvement in forced expiratory volume at 1 second (FEy1), in maximum midexpiratory flow (FEFn-75%), and in forced expiratory flow at 25 per cent of vital capacity (FEF25%) for 6 to 8 hours, whereas isoproterenol and isoetharine with phenylephrine produced improvement for 1 and 2 hours, respectively. The lowest dosage of fenoterol was as effective as the highest but had fewer adverse effects. F ENOTEROL hydrobromide, (1-3,5-dihydroxyphenyl)-1-hydroxy-2-(4-hydroxyphenylisopropylamino)ethane (TH 1 165a), structurally related to metaproterenol, is a relatively selective -adrenergic agonist with a prolonged duration of action.15 The purpose of this study was to compare fenoterol in three different doses with isoproterenol, isoetharine combined with phenylephrine, and a placebo, all delivered with an intermittent positive-pressure breathing (IPPB) device to young adults with uncomplicated asthma.

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تاریخ انتشار 2004